会议日程

Day 1 Thursday, November 15, 2018
08:45-08:55 Opening Organizers
08:55-09:00 Chair Muthiah Manoharan, PhD
09:00-09:45 Keynote Craig Mello, PhD, Professor, UMass Medical School, 2006 Nobel Prize in Physiology or Medicine, USA
Title: Phase-separated Domains of mRNA Regulation and Epigenetic Memory
09:45-10:20 Mikiko Siomi, PhD, Professor, The University of Tokyo, Japan
Title:piRNA Biogenesis and Functions
10:20-10:50 Refreshment Break & Poster Session
10:50-11:25 Chandrasekhar Kanduri, PhD, Professor in RNA Biology, University of Gothenburg, Sweden
Title: Functional and Mechanistic Roles of Long noncoding RNAs (lncRNAs) in Cancer Development and Progression
11:25-12:00 Andrew Yoo, PhD, Associate Professor, Washington University School of Medicine, USA
Title: MicroRNAs as Cell Fate Controllers and Cellular Reprogramming Factors
12:00-13:30 Lunch
13:30-13:35 Chair Laura Sepp-Lorenzino, PhD
13:35-14:20 Special
Invited Talk
Joseph Puglisi, PhD, Professor, Stanford University School of Medicine, Member of the US National Academy of Sciences, USA
Title: How mRNA Controls the Dynamics of Translation
14:20-14:55 Dong-ki Lee, PhD, Founder and CEO, OliX Pharmaceuticals, Korea
Title: Asymmetric siRNA Targeting Fibrotic and Ocular Disorders
14:55-15:30 Andreas Strasser, PhD, Division Head, Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Australia
Title: Towards Targeting MCL-1 for Cancer Therapy
15:30-16:00 Refreshment Break & Poster Session
16:00-16:35 Ekkehard Leberer, PhD, Senior Director, Sanofi, Germany
Title: Delivering Therapeutic Oligonucleotides Across Biobarriers: Opportunities and Challenges in Drug Development
16:35-17:10 Elisabetta Viani Puglisi, PhD, Senior Research Scientist, Stanford University School of Medicine, USA
Title: Architecture of the HIV-1 Reverse Transcriptase Initiation Complex
17:10-17:30 Technology Carina Andersson, Global Product Manager, GE Healthcare Life Sciences, Sweden
Title:
Manufacturing and Synthesis of Oligonucleotide Therapeutics from Process Development, through Clinical to Commercial Scale
17:30-17:50 Technology Alan LU, PhD, MBA, Executive Vice President, Sirnaomics, Inc, USA
Title:
Peptide Nano-particle (PNP) Delivering siRNA for the Treatment of Fibrosis and Cancer
17:50 End of Day 1
Day 2 Friday, November 16, 2018
08:55-09:00 Chair Mikiko Siomi, PhD
09:00-09:45 Keynote Bruce Sullenger, PhD, Professor, Duke University Medical Center, USA
Title: Translating RNA Aptamers into the Clinic and Back to the Lab
09:45-10:20 Muthiah Manoharan, PhD, Senior Vice President, Drug Discovery, Alnylam Pharmaceuticals, USA
Title: Advances in RNAi Therapeutics Using Chemistry
10:20-10:50 Refreshment Break & Poster Session
10:50-11:25 Zhen Li, PhD, Chemistry and Non-Clinical Development, Arrowhead Pharmaceuticals, USA
Title: TRiMTM Platform Based RNAi Therapeutics in Treating HBV and Cardiometabolic Diseases
11:25-12:00 Laura Sepp-Lorenzino, PhD, Vice President, Head of Nucleic Acid Therapies, Vertex Pharmaceuticals, USA
Title: Innovation at Vertex: Nucleic Acid Therapies as Transformative Medicines
12:00-13:30 Lunch
13:30-13:35 Chair Chandrasekhar Kanduri, PhD
13:35-14:10 Ailong Ke, PhD, Professor, Cornell University, USA
Title: Spacer Acquisition Mechanism in Type II-A CRISPR System
14:10-14:45 Wei Li, PhD, Professor of Bioinformatics, Baylor College of Medicine, USA
Title: 3ʹ-UTR Shortening Represses Tumor Suppressor Genes in trans by Disrupting ceRNA Crosstalk
14:45-15:20 Tetsuro Hirose, PhD, Professor, Hokkaido University, Japan
Title: Nuclear Architecture by Long noncoding RNAs through Phase Separation
15:20-15:50 Refreshment Break & Poster Session
15:50-16:25 Housheng Hansen He, PhD, Associate Professor, University of Toronto, Canada
Title: Genetic Variation, Noncoding RNA and Chromatin Regulation
16:25-17:00 Laura Croft, PhD, Senior Research Fellow, Queensland University of Technology, Australia
Title: Targeting DNA Repair Pathways in Cancer Using Oligonucleotides
17:00-17:10 Poster Awards
17:10-17:20 Closing Craig Mello, PhD, Professor, UMass Medical School, 2006 Nobel Prize in Physiology or Medicine, USA

       论坛起源于广州核酸国际论坛,在政府及各界支持下已经连续举办了五届,历届大会报告人汇集诺贝尔奖得主在内的全球顶级科学家、学者和企业家,论坛聚焦精准医学、生命科学、基因治疗、核酸药开发等最新热点进展,分享来自全球范围内核酸研究及应用的重大成果和进展。中国核酸国际论坛(CNAF)的知名度与影响力也受到国际学术界与企业界的高度赞誉,被誉为中国核酸研究与产业化的重要风向标。