Day 1 Thursday, November 15, 2018
08:45-08:55 Opening Organizers
08:55-09:00 Chair Muthiah Manoharan, PhD
09:00-09:45 Keynote Craig Mello, PhD, Professor, UMass Medical School, 2006 Nobel Prize in Physiology or Medicine, USA
Title: Phase-separated Domains of mRNA Regulation and Epigenetic Memory
09:45-10:20 Mikiko Siomi, PhD, Professor, The University of Tokyo, Japan
Title: piRNA Biogenesis and Functions
10:20-10:50 Refreshment Break & Poster Session
10:50-11:25 Chandrasekhar Kanduri, PhD, Professor in RNA Biology, University of Gothenburg, Sweden
Title: Functional and Mechanistic Roles of Long noncoding RNAs (lncRNAs) in Cancer Development and Progression
11:25-12:00 Andrew Yoo, PhD, Associate Professor, Washington University School of Medicine, USA
Title: MicroRNAs as Cell Fate Controllers and Cellular Reprogramming Factors
12:00-13:30 Lunch
13:30-13:35 Chair Laura Sepp-Lorenzino, PhD
13:35-14:20 Special
Invited Talk
Joseph Puglisi, PhD, Professor, Stanford University School of Medicine, Member of the US National Academy of Sciences, USA
Title: How mRNA Controls the Dynamics of Translation
14:20-14:55 Dong-ki Lee, PhD, Founder and CEO, OliX Pharmaceuticals, Korea
Title: Asymmetric siRNA Targeting Fibrotic and Ocular Disorders
14:55-15:30 Andreas Strasser, PhD, Division Head, Molecular Genetics of Cancer, The Walter and Eliza Hall Institute of Medical Research, Australia
Towards Targeting MCL-1 for Cancer Therapy
15:30-16:00 Refreshment Break & Poster Session
16:00-16:35 Ekkehard Leberer, PhD, Senior Director, Sanofi, Germany
Title: Delivering Therapeutic Oligonucleotides Across Biobarriers: Opportunities and Challenges in Drug Development
16:35-17:10 Elisabetta Viani Puglisi, PhD, Senior Research Scientist, Stanford University School of Medicine, USA
Title: Architecture of the HIV-1 Reverse Transcriptase Initiation Complex
17:10-17:30 Technology Carina Andersson, Global Product Manager, GE Healthcare Life Sciences, Sweden
Title: Manufacturing and Synthesis of Oligonucleotide Therapeutics from Process Development, through Clinical to Commercial Scale
17:30-17:50 Technology Alan LU, PhD, MBA, Executive Vice President, Sirnaomics, Inc, USA
Peptide Nano-particle (PNP) Delivering siRNA for the Treatment of Fibrosis and Cancer
17:50 End of Day 1
Day 2 Friday, November 16, 2018
08:55-09:00 Chair Mikiko Siomi, PhD
09:00-09:45 Keynote Bruce Sullenger, PhD, Professor, Duke University Medical Center, USA
Title: Translating RNA Aptamers into the Clinic and Back to the Lab
09:45-10:20 Muthiah Manoharan, PhD, Senior Vice President, Drug Discovery, Alnylam Pharmaceuticals, USA
Title: Advances in RNAi Therapeutics Using Chemistry
10:20-10:50 Refreshment Break & Poster Session
10:50-11:25 Zhen Li, PhD, Senior Vice President, Chemistry and Non-Clinical Development, Arrowhead Pharmaceuticals, USA
Title: TRiMTM Platform Based RNAi Therapeutics in Treating HBV and Cardiometabolic Diseases
11:25-12:00 Laura Sepp-Lorenzino, PhD, Vice President, Head of Nucleic Acid Therapies, Vertex Pharmaceuticals, USA
Title: Innovation at Vertex: Nucleic Acid Therapies as Transformative Medicines
12:00-13:30 Lunch
13:30-13:35 Chair Chandrasekhar Kanduri, PhD
13:35-14:10 Ailong Ke, PhD, Professor, Cornell University, USA
Title: Spacer Acquisition Mechanism in Type II-A CRISPR System
14:10-14:45 Wei Li, PhD, Professor of Bioinformatics, Baylor College of Medicine, USA
Title: 3ʹ-UTR Shortening Represses Tumor Suppressor Genes in trans by Disrupting ceRNA Crosstalk
14:45-15:20 Tetsuro Hirose, PhD, Professor, Hokkaido University, Japan
Nuclear Architecture by Long noncoding RNAs through Phase Separation
15:20-15:50 Refreshment Break & Poster Session
15:50-16:25 Housheng Hansen He, PhD, Associate Professor, University of Toronto, Canada
Title: Genetic Variation, Noncoding RNA and Chromatin Regulation
16:25-17:00 Laura Croft, PhD, Senior Research Fellow, Queensland University of Technology, Australia
Title: Targeting DNA Repair Pathways in Cancer Using Oligonucleotides
17:00-17:10 Poster Awards
17:10-17:20 Closing Craig Mello, PhD, Professor, UMass Medical School, 2006 Nobel Prize in Physiology or Medicine, USA


      Nucleic acids science plays a key role in precision medicine, genetic therapy and new solutions for human health. Continuous discovery of new RNA functions and constant emergence of innovative nucleic acids technologies are driving forces for the field and hold enormous promise for the future scientific and technological progress. The China Nucleic Acids Forum (CNAF) led by Nobel Prize winners is an international forum at the forefront of these developments, aims to push forward communications and collaborations in and abroad, and has been successfully held five times since 2013. The CNAF has attracted high-profile speakers, including Nobel Prize winners, to highlight recent advances in nucleic-acid based medicine, scientific discoveries, diagnostics and industrial trends. It has been widely recognized as the premier forum in Asia for advancing nucleic acids research and drug development. The 2018 CNAF will feature 20+ globally prominent experts discussing the latest advances in nucleic acids research and development.

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